I've been using both of these in UU with good results.
Moveset Name: Nessy's Last Song
Move 1: Block
Move 2: Perish Song
Move 3: Protect
Move 4: Dive / Substitute / Rest
Item: Leftovers
Ability: Water Absorb
Nature(s): Bold
EVs: 4 HP / 252 Def / 252 SpDef
Idea: Lapras with Block now gives stiff competition to Mismagius as the best Perish Trapper in OU. Larpas does have many advantages to the speeder ghost though. Firstly, Lapras has better bulk on both sides of the spectrum, letting it shrug off neutral hits, and even Super Effective hits from weaker walls. Lapras also has the ability to heal itself with giving up a move slot in the form of Water Absorb.
The final move slot is open to discussion. Dive gives Lapras a tool against any Taunter it may trap, and allows it to stall out Perish Song. Protect/Attack/Protect is just as handy though if you decide another Attack will help. Substitute allows Lapras to once against stall Perish Song, while Rest allows Lapras to stay alive, and keep trapping later in the match.
Support: Lapras works well with a team that have entry hazards on the field. Failing to trap, Perish Song is a move that will cause many switches, racking up Stealth Rocks and Spikes damage. Froslass sets up Spikes, and helps Lapras take the strong fighting attacks of UU. Nidoqueen can take Fighting, Electric, and most Grass attacks aimed at Lapras, and setup Stealth Rocks, or Toxic Spikes to aid the effort.
Moveset Name: Not Ambipom
Move 1: Fake Out
Move 2: Return
Move 3: Hammer Arm / Brick Break
Move 4: Toxic / Yawn
Item: Leftovers
Ability: Scrappy
Nature(s): Adamant
EVs: 252 HP / 200 Att / 52 Def
Idea: Kangaskhan makes a terrific lead in the current UU metagame. With the EVs give, Khan has enough power to Fake Out Froslass, and destroy it with Hammer Arm 100% of the time (as long as Hammer Arm hits). Likewise, even the bulkiest Spiritomb will fall to Fake Out and two Hammer Arms.
Hammer Arm is the prefered Fighting attack, providing even power to threaten Spiritomb, Cloyster, Omastar and the critical secured OHKO on Froslass (after Fake Out). Although, if the user is concerned with Screen users, or wants to run Yawn on the moveset, Brick Break is an option. Focus Punch is another option, but much risker. Without Substitute, you'll have to count on Taunt/entry hazards being setup. It can put Cloyster within Return's KO range though.
Yawn can be a great way to deal with Leads Khan would otherwise have no answer for, such as Steelix and Moltres. Toxic however, when combined with Kangaskhan's bulk, is a good option overall.
Support: Kangaskhan appreciates Pokemon that can remove its counters, and that can take its Fighting attacks. The largest issue for Khan is the ability to damage incredibly bulky Leads like Uxie, Cloyster, and Steelix. A strong Pursuit user, like Spiritomb, or Honchkrow will scare off Uxie. Bulky Waters like Slowbro, and Milotic don't mind taking on Cloyster, or Steelix. Slowbro in particular is a nice partner for Khan, as it resist Fighting, and Khan is immune to Ghost type attacks.